Article
Evolution of mutational robustness in the yeast genome: a link to essential genes and meiotic recombination hotspots.
PLoS genetics - 1 Jun 2009
Keller Philipp J, Knop Michael
Abstract excerpt
Deleterious mutations inevitably emerge in any evolutionary process and are speculated to decisively influence the structure of the genome. Meiosis, which is thought to play a major role in handling mutations on the population level, recombines chromosomes via non-randomly distributed hot spots for meiotic recombination. In many genomes, various types of genetic elements are distributed in patterns that are...
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