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Article

Contrasting genetic paths to morphological and physiological evolution.

Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2010

Liao Ben-Yang, Weng Meng-Pin, Zhang Jianzhi

Abstract excerpt

The relative importance of protein function change and gene expression change in phenotypic evolution is a contentious, yet central topic in evolutionary biology. Analyzing 5,199 mouse genes with recorded mutant phenotypes, we find that genes exclusively affecting morphological traits when mutated (dubbed "morphogenes") are grossly enriched with transcriptional regulators, whereas those exclusively affecting...

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PMID: 20368429
DOI: 10.1073/pnas.0910339107
PMCID: PMC2867737

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