Article
Ganciclovir-resistant cytomegalovirus encephalitis in a hematopoietic stem cell transplant recipient.
Journal of neurovirology - 1 Mar 2010
Arslan Ferhat, Tabak Fehmi, Avşar Emin, Midilli Kenan, Mert Ali, Ozaras Resat, Soysal Teoman, Ozturk Recep, Ferhanoglu Burhan
Abstract excerpt
We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV) retinitis and encephalitis under the ganciclovir maintenance treatment. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid and blood showed CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance....
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