Article
Functional assays for hematopoietic stem cell self-renewal.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
Perry John M, Li Linheng
Abstract excerpt
Stem cells are defined by the ability to self-renew. Specific functional assays have been developed for the rigorous identification and quantification of hematopoietic stem cells (HSCs), making these cells the benchmark in studies of self-renewal. Here, we review the theory behind these functional stem cell tests and discuss important considerations in choosing and designing these assays. Finally, we provide a...
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