Article
Linkage analysis and functional evaluation of inherited clinical pain conditions.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
Krupp Johannes J, Hellgren Dennis, Eriksson Anders B
Abstract excerpt
Because ion channel function is a fundamental element of any nociceptive signalling, it is not surprising that numerous channelopathies have recently emerged as likely causes of several inherited clinical pain conditions. For example, numerous missense mutations in the Na(v)1.7 gene SCN9A have recently been linked to a congenital inability to sense pain. Establishing the link between a clinical pain phenotype to...
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