The "soft collagen" hypothesis in the pathogenesis of the inflammatory bowel disease and the seronegative spondylarthritides.

Abstract excerpt

Seronegative spondylarthritides (SpAs) and inflammatory bowel disease (IBD) are disorders with a complex and elusive etiology. Current research has focused on downstream events and mechanisms of autoimmunity and inflammation but the primary etiologic factor is still unknown. We present a new hypothesis for the role of collagen into the pathogenesis of SpAs and IBD based on the assumption that they represent...

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