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Article

Thymidylate synthase (TYMS) enhancer region genotype-directed phase II trial of oral capecitabine for 2nd line treatment of advanced pancreatic cancer.

Investigational new drugs - 1 Oct 2011

Weekes Colin D, Nallapareddy Sujatha, Rudek Michelle A, Norris-Kirby Alexis, Laheru Daniel, Jimeno Antonio, Donehower Ross C, Murphy Kathleen M, Hidalgo Manuel, Baker Sharyn D, Messersmith Wells A

Abstract excerpt

PURPOSE: The primary aim of this study was to characterize the 6-month overall survival and toxicity associated with second-line capecitabine treatment of advanced pancreatic cancer patients harboring the TYMS *2/*2 allele. The secondary aim was to analyze the response rate and pharmacokinetics o...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20306339
DOI: 10.1007/s10637-010-9413-7
PMCID: PMC3110647

Genes

TYMS
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20306339-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Thymidylate synthase (TYMS) enhancer region genotype-directed phase II trial of oral capecitabine for 2nd line treatment of advanced pancreatic cancer.PMID 20306339Read ↗

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