Lineage-specific transcription factor aberrations in AML.

doi:10.1007/978-0-387-69259-3_7

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Article

Lineage-specific transcription factor aberrations in AML.

Cancer treatment and research - 1 Jan 2010

Mueller Beatrice U, Pabst Thomas

Abstract excerpt

Transcription factors play a key role in the commitment of hematopoietic stem cells to differentiate into specific lineages [78]. This is particularly important in that a block in terminal differentiation is the key contributing factor in acute leukemias. This general theme of the role of transcr...

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