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Article

Reduced survival of type 2B von Willebrand factor, irrespective of large multimer representation or thrombocytopenia.

Haematologica - 1 Aug 2010

Casonato Alessandra, Gallinaro Lisa, Cattini Maria Grazia, Pontara Elena, Padrini Roberto, Bertomoro Antonella, Daidone Viviana, Pagnan Antonio

Abstract excerpt

BACKGROUND: Type 2B von Willebrand factor (VWF) is characterized by gain of function mutations in the A1 domain inducing a greater affinity for platelet GPIb, possibly associated with the disappearance of large VWF multimers and thrombocytopenia. DESIGN AND METHODS: VWF survival was explored using 1-desamino-8-D-arginine vasopressin (DDAVP) in 18 patients with type 2B von Willebrand disease (VWD) and compared...

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Identifiers

PMID: 20305138
DOI: 10.3324/haematol.2009.019927
PMCID: PMC2913086

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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