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Article

Next-generation sequencing and large genome assemblies.

Pharmacogenomics - 1 Jun 2012

Henson Joseph, Tischler German, Ning Zemin

Abstract excerpt

The next-generation sequencing (NGS) revolution has drastically reduced time and cost requirements for sequencing of large genomes, and also qualitatively changed the problem of assembly. This article reviews the state of the art in de novo genome assembly, paying particular attention to mammalian-sized genomes. The strengths and weaknesses of the main sequencing platforms are highlighted, leading to a discussion...

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PMID: 22676195
DOI: 10.2217/pgs.12.72
PMCID: PMC3960634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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