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Article

Is There a Predisposition Gene for Ewing's Sarcoma?

1 Jan 2010

Abstract excerpt

Ewing's sarcoma is a highly malignant tumor of children and young adults. The molecular mechanisms that underlie Ewing's Sarcoma development are beginning to be understood. For example, most cases of this disease harbor somatic chromosomal translocations that fuse the EWSR1 gene on chromosome 22 with members of the ETS family. While some cooperative genetic events have been identified, such as mutations in TP53...

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Identifiers

PMID: 20300555
DOI: 10.1155/2010/397632

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