Article
Reduction of fatty acid flux results in enhancement of astaxanthin synthesis in a mutant strain of Phaffia rhodozyma.
Journal of industrial microbiology & biotechnology - 1 Jun 2010
Miao Lili, Wang Yongxing, Chi Shuang, Yan Jiacong, Guan Guohua, Hui Bodi, Li Ying
Abstract excerpt
A moderate-temperature mutant strain of the yeast Phaffia rhodozyma, termed MK19, was selected by 1-methyl-3-nitro-1-nitrosoguanidine (NTG) and Co60 mutagenesis. MK19 displayed fast cell growth and elevated astaxanthin content at 25 degrees C, whereas optimal temperature for growth and astaxanthin synthesis of wild-type P. rhodozyma was 17-21 degrees C. Optimized astaxanthin yield for MK19 after 4 days culture in...
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