Article
Dtorsin, the Drosophila ortholog of the early-onset dystonia TOR1A (DYT1), plays a novel role in dopamine metabolism.
PloS one - 1 Jan 2011
Wakabayashi-Ito Noriko, Doherty Olugbenga M, Moriyama Hideaki, Breakefield Xandra O, Gusella James F, O'Donnell Janis M, Ito Naoto
Abstract excerpt
Dystonia represents the third most common movement disorder in humans. At least 15 genetic loci (DYT1-15) have been identified and some of these genes have been cloned. TOR1A (formally DYT1), the gene responsible for the most common primary hereditary dystonia, encodes torsinA, an AAA ATPase family protein. However, the function of torsinA has yet to be fully understood. Here, we have generated and characterized...
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