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Article

CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus.

Molecular cancer - 8 Mar 2010

Elmetwali Taha, Searle Peter F, McNeish Iain, Young Lawrence S, Palmer Daniel H

Abstract excerpt

BACKGROUND: CD40 and its ligand (CD40L) play a critical role in co-ordinating immune responses. CD40 is also expressed in lymphoid malignancies and a number of carcinomas. In carcinoma cells the physiological outcome of CD40 ligation depends on the level of receptor engagement with low levels pro...

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Identifiers

PMID: 20211016
DOI: 10.1186/1476-4598-9-52
PMCID: PMC2847953

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20211016-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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