Article
Beta-catenin mutations are not observed in chronic myeloid leukemia.
Tumori - 1 Jan 2000
Sercan Zeynep, Pehlivan Melek, Gokturk Dilek, Sercan Hakki Ogun
Abstract excerpt
AIMS AND BACKGROUND: Studies reporting activated Wnt signaling in all stages of chronic myeloid leukemia (CML) have demonstrated that deregulation of the pathway plays a role in the pathogenesis of this disease. Several reports have suggested mechanisms for the deregulated Wnt signaling and beta-catenin stabilization observed in CML. One possible mechanism for beta-catenin stabilization could be the acquisition...
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