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Article

Genetic and phenotypic differences between sexes in congenital hypogonadotropic hypogonadism (CHH): Large cohort analysis from a single tertiary centre.

Frontiers in endocrinology - 1 Jan 2022

Federici Silvia, Cangiano Biagio, Goggi Giovanni, Messetti Dario, Munari Elisabetta Veronica, Amer Myriam, Giovanelli Luca, Hrvat Faris, Vezzoli Valeria, Persani Luca, Bonomi Marco

Abstract excerpt

Background: Congenital hypogonadotropic hypogonadism (CHH) is a condition with a strong genetic background, caused by a deficient production, secretion, or action of gonadotropin-releasing hormone (GnRH). Published data on CHH cohorts indicate a male predominance, although this is not supported by our current understandings. Aims: In order to unravel the possible causes or contributors to such epidemiological sex...

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PMID: 36531499
DOI: 10.3389/fendo.2022.965074
PMCID: PMC9755160

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