Article
Effects of folic acid supplementation on the pharmacokinetics and anticoagulant effect of warfarin: an open-label, prospective study of long-term administration in adults.
Clinical therapeutics - 1 Feb 2010
Muszkat Mordechai, Bialer Omer, Blotnick Simcha, Adar Liat, Xie Hong-Guang, Ufer Mike, Cascorbi Ingolf, Caraco Yoseph
Abstract excerpt
BACKGROUND: Folic acid supplementation in patients with folic acid deficiency has been associated with increased clearance of phenytoin to its cytochrome P450 (CYP) 2C9-mediated metabolite, 5-(4'-hydroxyphenyl)-5-phenylhydantoin. OBJECTIVE: The aim of this study was to determine whether folic acid supplementation increases the dosage requirement of the CYP2C9 substrate warfarin, and the formation clearance of the...
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