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Article

Detection of exon 12 Mutations in the JAK2 gene: enhanced analytical sensitivity using clamped PCR and nucleotide sequencing.

The Journal of molecular diagnostics : JMD - 1 May 2010

Laughlin Todd S, Moliterno Alison R, Stein Brady L, Rothberg Paul G

Abstract excerpt

JAK2 V617F is the most frequently found somatic mutation in polycythemia vera (PV). Among the cases negative for V617F, a significant fraction have a mutation in exon 12 of the JAK2 gene. Several groups have reported that the exon 12 mutations are present in only a small fraction of the blood cel...

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Identifiers

PMID: 20203004
DOI: 10.2353/jmoldx.2010.090177
PMCID: PMC2860462

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20203004-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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