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Article

Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran.

Genetics and molecular research : GMR - 9 Feb 2010

Marjani H A, Biramijamal F, Rakhshani N, Hossein-Nezhad A, Malekzadeh R

Abstract excerpt

We evaluated the effect of NQO1 genetic variation on PAH-DNA adducts in esophageal squamous cell carcinoma (ESCC) in northeast Iran. Golestan Province in northeast of Iran has one of the highest esophageal cancer incidences in the world. The study included 93 ESCC cases and 50 control individuals who were seen at the clinical cancer center in Golestan province. NQO1 C609T genotypes were determined by PCR-RFLP...

Topics

Aged
Carcinoma, Squamous Cell
Case-Control Studies
DNA Adducts
Esophageal Neoplasms
Female
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Humans
Iran

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

NAD(P)H Dehydrogenase (Quinone)

Polycyclic Aromatic Hydrocarbons

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 20198579
DOI: 10.4238/vol9-1gmr693

Genes

NQO1
PAH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20198579-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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