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Article

Composite interval mapping to identify quantitative trait loci for point-mass mixture phenotypes.

Genetics research - 1 Feb 2010

Taylor Sandra L, Pollard Katherine S

Abstract excerpt

Increasingly researchers are conducting quantitative trait locus (QTL) mapping in metabolomics and proteomics studies. These data often are distributed as a point-mass mixture, consisting of a spike at zero in combination with continuous non-negative measurements. Composite interval mapping (CIM) is a common method used to map QTL that has been developed only for normally distributed or binary data. Here we...

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PMID: 20196895
DOI: 10.1017/S0016672310000042

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