Article
Lack of genotype effect on D1, D2 receptors and dopamine transporter binding in triple MOP-, DOP-, and KOP-opioid receptor knockout mice of three different genetic backgrounds.
Synapse (New York, N.Y.) - 1 Jul 2010
Yoo Ji-Hoon, Bailey Alexis, Ansonoff Micheal, Pintar John E, Matifas Audrey, Kieffer Brigitte L, Kitchen Ian
Abstract excerpt
We investigated D1, D2 receptors and dopamine transporter (DAT) binding levels in mice lacking all three opioid receptors and wild-type (WT) mice on three different genetic backgrounds. Quantitative autoradiography was used to determine the level of radioligand binding to the D1 and D2 receptors and DAT labeled with [(3)H]SCH23390, [(3)H]raclopride, and [(3)H]mazindol, respectively in triple-opioid receptor...
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