Stage‐specific global alterations in the transcriptomes of <scp>L</scp>yme disease spirochetes during tick feeding and following mammalian host adaptation

Abstract excerpt

Borrelia burgdorferi, the agent of Lyme disease, is maintained in nature within an enzootic cycle involving a mammalian reservoir and an Ixodes sp. tick vector. The transmission, survival and pathogenic potential of B. burgdorferi depend on the bacterium's ability to modulate its transcriptome as it transits between vector and reservoir host. Herein, we employed an amplification-microarray approach to define the...

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