Article
Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis.
Journal of the National Cancer Institute - 17 Mar 2010
Lee Mi-Ni, Lee Shi-Nai, Kim Se-Hee, Kim Bora, Jung Bo-Kyung, Seo Ji Hae, Park Ji-Hyeon, Choi Jae-Hoon, Yim Sun Hee, Lee Mi-Ran, Park Jong-Gil, Yoo Ji-Young, Kim Jeong Hun, Lee Seung-Taek, Kim Hwan-Mook, Ryeom Sandra, Kim Kyu-Won, Oh Goo Taeg
Abstract excerpt
BACKGROUND: Vascular endothelial growth factor A (VEGFA), a critical mediator of tumor angiogenesis, is a well-characterized target of hypoxia-inducible factor 1 (HIF-1). Murine arrest-defective protein 1A (mARD1A(225)) acetylates HIF-1alpha, triggering its degradation, and thus may play a role i...
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