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Thyroid Hormone Receptor Alpha Is Required for Thyroid Hormone-Dependent Neural Cell Proliferation During Tadpole Metamorphosis

28 Jun 2019

Abstract excerpt

Thyroid hormone (T3) plays key roles in nervous system development in vertebrates, controlling diverse processes such as neurogenesis, cell migration, apoptosis, differentiation and maturation. In anuran amphibians, the hormone exerts its actions on the tadpole brain during metamorphosis, a developmental period entirely dependent on T3. Thyroid hormone regulates gene transcription by binding to two nuclear...

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PMID: 31316462
DOI: 10.3389/fendo.2019.00396

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