[Study on telomerase gene mutation in northern Chinese patients with acquired bone marrow failure syndromes.].

Abstract excerpt

OBJECTIVE: To study the frequency of telomerase gene (TERC and TERT) mutation in Northern Chinese patients with acquired bone marrow failure syndromes (BMFS). METHODS: DNA extracted from blood samples of 90 patients with BMFS (including AA, MDS, and PNH) and 45 normal controls from 4 northern hospitals was collected. TERC and TERT mutation analysis was performed by PCR. RESULTS: Two TERC mutations (n37 A-->G, and...

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