Article
Mutations in telomerase catalytic protein in Japanese children with aplastic anemia.
Haematologica - 1 May 2006
Liang Juan, Yagasaki Hiroshi, Kamachi Yoshiro, Hama Asahito, Matsumoto Kimikazu, Kato Kouji, Kudo Kazuko, Kojima Seiji
Abstract excerpt
Recent studies indicate that a subset of patients with apparently acquired aplastic anemia (AA) have mutations in genes for telomerase ribonucleoprotein complex components. We looked for mutations in telomerase RNA (TERC) and telomerase reverse transcriptase (TERT) in 96 Japanese children with acquired AA and in 76 healthy controls. No mutations in TERC were found in any subjects. Novel heterozygous,...
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