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Article

Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.

Bioorganic & medicinal chemistry - 15 Mar 2010

Opperman Timothy J, Williams John D, Houseweart Chad, Panchal Rekha G, Bavari Sina, Peet Norton P, Moir Donald T, Bowlin Terry L

Abstract excerpt

The bis-indoles are a novel class of compounds with potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative pathogens. The mechanism of action of these compounds has not been clearly defined. To study the mechanism of action of bis-indoles, selections for mutants...

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Source

Identifiers

PMID: 20188576
DOI: 10.1016/j.bmc.2010.02.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20188576-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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