Injury of rat pulmonary alveolar epithelial cells by H2O2: dependence on phenotype and catalase.

doi:10.1152/ajplung.1991.260.4.L318

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Article

Injury of rat pulmonary alveolar epithelial cells by H2O2: dependence on phenotype and catalase.

The American journal of physiology - 1 Apr 1991

Simon R H, Edwards J A, Reza M M, Kunkel R G

Abstract excerpt

In a variety of inflammatory lung diseases, type I alveolar epithelial cells are more likely to be injured than are type II cells. Because oxidants have been implicated as a cause of injury in various inflammatory lung diseases, we evaluated the effects of differentiation on alveolar epithelial cell susceptibility to H2O2-induced injury. With the use of isolated rat type II cells in culture, we found that the...

Topics

Animals
Catalase
Cell Line
Cell Survival
Cells, Cultured
Epithelial Cells
Epithelium
Extracellular Matrix
Glucosephosphate Dehydrogenase
Glutathione
Glutathione Peroxidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutathione Reductase

Hydrogen Peroxide

Kinetics

Microscopy, Electron

Phenotype

Pulmonary Alveoli

Rats

Source

Open in PubMed

Identifiers

PMID: 2018152
DOI: 10.1152/ajplung.1991.260.4.L318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2018152-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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