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Article

Biomarkers and surrogate endpoints for normal-tissue effects of radiation therapy: the importance of dose-volume effects.

International journal of radiation oncology, biology, physics - 1 Mar 2010

Bentzen Søren M, Parliament Matthew, Deasy Joseph O, Dicker Adam, Curran Walter J, Williams Jacqueline P, Rosenstein Barry S

Abstract excerpt

Biomarkers are of interest for predicting or monitoring normal tissue toxicity of radiation therapy. Advances in molecular radiobiology provide novel leads in the search for normal tissue biomarkers with sufficient sensitivity and specificity to become clinically useful. This article reviews examples of studies of biomarkers as predictive markers, as response markers, or as surrogate endpoints for radiation side...

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Biomarkers
Cytokines
Dose-Response Relationship, Radiation
Radiation Injuries
Radiation Tolerance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Terminology as Topic

Transforming Growth Factor beta1

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PMID: 20171510
DOI: 10.1016/j.ijrobp.2009.08.076
PMCID: PMC3431963

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