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Article

Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis.

BMC microbiology - 18 Feb 2010

Movahedzadeh Farahnaz, Wheeler Paul R, Dinadayala Premkumar, Av-Gay Yossef, Parish Tanya, Daffé Mamadou, Stoker Neil G

Abstract excerpt

BACKGROUND: Mycobacteria use inositol in phosphatidylinositol, for anchoring lipoarabinomannan (LAM), lipomannan (LM) and phosphatidylinosotol mannosides (PIMs) in the cell envelope, and for the production of mycothiol, which maintains the redox balance of the cell. Inositol is synthesized by conversion of glucose-6-phosphate to inositol-1-phosphate, followed by dephosphorylation by inositol monophosphate...

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Identifiers

PMID: 20167072
DOI: 10.1186/1471-2180-10-50
PMCID: PMC2834668

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