Article
Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification.
The Journal of biological chemistry - 15 Apr 1991
Huang C H, Blumenfeld O O
Abstract excerpt
Human glycophorins alpha and delta (or A and B) specify the MNSs blood group antigens; they exhibit considerable structural variation among populations. We show that two variant phenotypes of Miltenberger class III and VI are encoded by similar hybrid glycophorin genes in a delta-alpha-delta arrangement. Restriction mapping identified altered fragments unique to the MiIII and MiVI genes. Genomic sequences...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA
- Exons
- Gene Rearrangement
- Genetic Variation
- Glycophorins
- Humans
- MNSs Blood-Group System
- Molecular Sequence Data
- Nucleic Acid Hybridization