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Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status

26 Jul 2013

Abstract excerpt

INTRODUCTION: The reprogramming of a patient's somatic cells back into induced pluripotent stem cells (iPSCs) holds significant promise for future autologous cellular therapeutics. The continued presence of potentially oncogenic transgenic elements following reprogramming, however, represents a safety concern that should be addressed prior to clinical applications. The polycistronic stem cell cassette (STEMCCA),...

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PMID: 23890092
DOI: 10.1186/scrt246

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