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Natural killer cell receptors for major histocompatibility complex class I and related molecules in cytomegalovirus infection

16 Feb 2004

Abstract excerpt

Downmodulation of major histocompatibility complex (MHC) class I molecules by cytomegalovirus (CMV) impairs the engagement of specific leucocyte-inhibitory receptors, rendering infected cells vulnerable to natural killer (NK) cells. Members of the murine Ly49 and human KIR families, CD85j (ILT2 or leucocyte Ig-like receptor-1), as well as the CD94/NKG2A-inhibitory killer lectin-like receptor (KLR) fulfil this...

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PMID: 14989708
DOI: 10.1111/j.1399-0039.2004.00210.x

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