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Article

The genotype nucleophosmin mutated and FLT3-ITD negative is characterized by high bax/bcl-2 ratio and favourable outcome in acute myeloid leukaemia.

British journal of haematology - 1 May 2010

Del Poeta Giovanni, Ammatuna Emanuele, Lavorgna Serena, Capelli Giovanni, Zaza Serena, Luciano Fabrizio, Ottone Tiziana, Del Principe Maria Ilaria, Buccisano Francesco, Maurillo Luca, Panetta Paola, de Fabritiis Paolo, Stasi Roberto, Venditti Adriano, Amadori Sergio, Lo Coco Francesco

Abstract excerpt

Nucleophosmin gene (NPM1) mutations characterize acute myeloid leukaemia (AML) with normal karyotype and frequently co-exist with FLT3 internal tandem duplications (ITD). We evaluated bcl-2, bax, NPM1 and FLT3-ITD in 222 AML patients. Bax/bcl-2 ratio >0.35 and NPM1 without FLT3-ITD were significantly associated (P = 0.0001). NPM1-mutated (mt)/FLT3-ITD negative patients showed a higher complete remission (CR) rate...

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Share to bcl-2-Associated X Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 20148885
DOI: 10.1111/j.1365-2141.2010.08098.x

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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