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Article

Non-homologous end-joining gene profiling reveals distinct expression patterns associated with lymphoma and multiple myeloma.

British journal of haematology - 1 Apr 2010

Roddam Philippa L, Allan James M, Dring Ann M, Worrillow Lisa J, Davies Faith E, Morgan Gareth J

Abstract excerpt

Repair of DNA strand breaks induced during lymphoid antigen receptor rearrangement involves non-homologous end-joining (NHEJ). We investigated NHEJ in the aetiology of lymphoproliferative disorders (LPDs) and the disease subtypes therein through real-time quantitative RT-PCR gene expression analysis. Lower expression of XRCC6 and MRE11A was observed in all tumours, with higher expression of both XRCC4 and RAD50...

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Source

Identifiers

PMID: 20148879
DOI: 10.1111/j.1365-2141.2010.08088.x

Genes

RAD50
XRCC4
XRCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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