A murine model for type III tyrosinemia: lack of immunologically detectable 4-hydroxyphenylpyruvic acid dioxygenase enzyme protein in a novel mouse strain with hypertyrosinemia.

Abstract excerpt

We have characterized a new mutant strain of mouse that has hypertyrosinemia. The blood tyrosine level was persistently high, and increased amounts of 4-hydroxyphenylpyruvic acid and its derivatives were excreted into the urine. Succinylacetone was not detected in urine samples from these mice. All the animals were apparently healthy, and there was no evidence of hepatorenal dysfunction. The hypertyrosinemia was...

Topics

• 4-Hydroxyphenylpyruvate Dioxygenase
• Animals
• Chromatography, Gas
• Female
• Genes, Recessive
• Humans
• Liver
• Male
• Mice
• Models, Genetic
• Mutation