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SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations

15 Dec 2005

Abstract excerpt

MOTIVATION: The antigen receptors of adaptive immunity-T-cell receptors and immunoglobulins-are encoded by genes assembled stochastically from combinatorial libraries of gene segments. Immunoglobulin genes then experience further diversification through hypermutation. Analysis of the somatic genetics of the immune response depends explicitly on inference of the details of the recombinatorial process giving rise...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16357034
DOI: 10.1093/bioinformatics/btk004

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