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Article

Targeting of the cytosolic poly(A) binding protein PABPC1 to mitochondria causes mitochondrial translation inhibition.

Nucleic acids research - 1 Jun 2010

Wydro Mateusz, Bobrowicz Agnieszka, Temperley Richard J, Lightowlers Robert N, Chrzanowska-Lightowlers Zofia M

Abstract excerpt

Mammalian mitochondria contain their own genome that is almost fully transcribed from both strands, generating polycistronic RNA units that are processed and matured. The mitochondrial mRNA is modified by oligo- or polyadenylation at the 3' termini, but the exact function of this post-transcriptional addition is unclear. Current debate focuses on the role of polyadenylation in transcript stability. An equally...

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Source

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Identifiers

PMID: 20144953
DOI: 10.1093/nar/gkq068
PMCID: PMC2887948

Genes

PABPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeting of the cytosolic poly(A) binding protein PABPC1 to mitochondria causes mitochondrial translation inhibition.PMID 20144953Read ↗

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Alternative translation initiation augments the human mitochondrial proteome.Semantic proximity Read ↗

Direct and indirect consequences of <i>PAB1</i> deletion in the regulation of translation initiation, translation termination, and mRNA decaySemantic proximity Read ↗

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