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Article

ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus.

Molecular cancer research : MCR - 1 Feb 2010

Improgo Ma Reina D, Schlichting Nicolette A, Cortes Roxana Y, Zhao-Shea Rubing, Tapper Andrew R, Gardner Paul D

Abstract excerpt

Tobacco contains a variety of carcinogens as well as the addictive compound nicotine. Nicotine addiction begins with the binding of nicotine to its cognate receptor, the nicotinic acetylcholine receptor (nAChR). Genome-wide association studies have implicated the nAChR gene cluster, CHRNA5/A3/B4, in nicotine addiction and lung cancer susceptibility. To further delineate the role of this gene cluster in lung...

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Source

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Identifiers

PMID: 20124469
DOI: 10.1158/1541-7786.MCR-09-0185
PMCID: PMC2824774

Genes

ASCL1
CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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