Article
Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner.
The Journal of biological chemistry - 4 Sept 2009
Leverentz Michael K, Campbell Robert N, Connolly Yvonne, Whetton Anthony D, Reece Richard J
Abstract excerpt
Saccharomyces cerevisiae can utilize high quality (e.g. glutamine and ammonia) as well as low quality (e.g. gamma-amino butyric acid and proline) nitrogen sources. The transcriptional activator Put3p allows yeast cells to utilize proline as a nitrogen source through expression of the PUT1 and PUT2 genes. Put3p activates high level transcription of these genes by binding proline directly. However, Put3p also...
Topics
- Antifungal Agents
- GATA Transcription Factors
- Gene Expression Regulation, Fungal
- Mutation
- Phosphorylation
- Proline
- Proline Oxidase
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sirolimus
- Transcription Factors
- Transcription, Genetic