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Article

Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease.

The Journal of biological chemistry - 9 Apr 2010

Graham Brett H, Li Zhihong, Alesii Erminio P, Versteken Patrik, Lee Cynthia, Wang Jennifer, Craigen William J

Abstract excerpt

Voltage-dependent anion channels (VDACs) are a family of small pore-forming proteins of the mitochondrial outer membrane found in all eukaryotes. VDACs play an important role in the regulated flux of metabolites between the cytosolic and mitochondrial compartments, and three distinct mammalian isoforms have been identified. Animal and cell culture experiments suggest that the various isoforms act in disparate...

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Identifiers

PMID: 20110367
DOI: 10.1074/jbc.M109.080317
PMCID: PMC2856991

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