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New insights into Trypanosoma cruzi genetic diversity, and its influence on parasite biology and clinical outcomes.

Frontiers in immunology - 1 Jan 2024

Silvestrini Marina Malheiros Araújo, Alessio Glaucia Diniz, Frias Bruna Estefânia Diniz, Sales Júnior Policarpo Ademar, Araújo Márcio Sobreira Silva, Silvestrini Carolina Malheiros Araújo, Brito Alvim de Melo Gustavo Eustáquio, Martins-Filho Olindo Assis, Teixeira-Carvalho Andréa, Martins Helen Rodrigues

Abstract excerpt

Chagas disease, caused by Trypanosoma cruzi, remains a serious public health problem worldwide. The parasite was subdivided into six distinct genetic groups, called "discrete typing units" (DTUs), from TcI to TcVI. Several studies have indicated that the heterogeneity of T. cruzi species directly affects the diversity of clinical manifestations of Chagas disease, control, diagnosis performance, and susceptibility...

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Identifiers

PMID: 38655255
DOI: 10.3389/fimmu.2024.1342431
PMCID: PMC11035809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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