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Article

Mutation H63D in the HFE gene confers risk for the development of type 2 diabetes mellitus but not for chronic complications.

Journal of diabetes and its complications - 1 Jan 2000

Colli Máikel L, Gross Jorge L, Canani Luis H

Abstract excerpt

PURPOSE: To evaluate the frequency of mutations in the HFE gene (C282Y and H63D) in type 2 diabetes mellitus (DM) patients and their possible association with diabetic chronic complications. METHODS: A case-control study with 723 subjects was performed. All diabetic subjects (n=519) underwent a c...

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Source

Identifiers

PMID: 20097100
DOI: 10.1016/j.jdiacomp.2009.12.002

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20097100-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation H63D in the HFE gene confers risk for the development of type 2 diabetes mellitus but not for chronic complications.PMID 20097100Read ↗

The HFE gene is associated to an earlier age of onset and to the presence of diabetic nephropathy in diabetes mellitus type 2.Semantic proximity Read ↗

Correlation between HFE gene polymorphisms and increased risk of coronary artery disease among patients with type 2 diabetes in Iran.Semantic proximity Read ↗

A search for association between hereditary hemochromatosis HFE gene mutations and type 2 diabetes mellitus in a Polish population.Semantic proximity Read ↗

Prevalence, characteristics, and prognostic significance of HFE gene mutations in type 2 diabetes: the Fremantle Diabetes Study.Semantic proximity Read ↗

Hemochromatosis gene (HFE) polymorphisms and risk of type 2 diabetes mellitus: a meta-analysis.Semantic proximity Read ↗

Relations among serum ferritin, C282Y and H63D mutations in the HFE gene and type 2 diabetes mellitus in the Czech population.Semantic proximity Read ↗

Hemochromatosis gene (HFE) mutations in patients with type 2 diabetes and their control group in an Iranian population.Semantic proximity Read ↗

Lack of association of HFE gene polymorphism with high body iron status in Pakistani patients with type 2 diabetes mellitus.Semantic proximity Read ↗

Haemochromatosis-causing mutations C282Y and H63D are not risk factors for coronary artery disease in Caucasians with type 2 diabetes.Semantic proximity Read ↗

Typical type 2 diabetes mellitus and HFE gene mutations: a population-based case - control study.Semantic proximity Read ↗

Lack of association of C282Y and H63D mutations in the hemochromatosis (HFE) gene with diabetes mellitus type 2 in a case-control study of women in Brazil.Semantic proximity Read ↗

HFE genetic variability, body iron stores, and the risk of type 2 diabetes in U.S. women.Semantic proximity Read ↗

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