Fluorescence In Situ Hybridization Testing for −5/5q, −7/7q, +8, and del(20q) in Primary Myelodysplastic Syndrome Correlates With Conventional Cytogenetics in the Setting of an Adequate Study

Abstract excerpt

Multiple studies, with differing results, have compared the added sensitivity of fluorescence in situ hybridization (FISH) with conventional cytogenetics (CC) to detect genetic abnormalities in myelodysplastic syndrome (MDS). We hypothesized that in the setting of an adequate CC study, FISH would correlate with microscopic genetic abnormalities involving chromosomes 5, 7, 8, and 20. We performed FISH for -5/5q,...

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