Article
Serum metabolome analysis by 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups.
Leukemia - 1 Apr 2010
MacIntyre D A, Jiménez B, Lewintre E Jantus, Martín C Reinoso, Schäfer H, Ballesteros C García, Mayans J Ramón, Spraul M, García-Conde J, Pineda-Lucena A
Abstract excerpt
Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease exhibiting variable clinical course and survival rates. Mutational status of the immunoglobulin heavy chain variable regions (IGHVs) of CLL cells offers useful prognostic information for high-risk patients, but time and economical costs originally prevented it from being routinely used in a clinical setting. Instead, alternative markers of IGHV...
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