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Article

Metabolic phenotyping for enhanced mechanistic stratification of chronic hepatitis C-induced liver fibrosis.

The American journal of gastroenterology - 1 Jan 2015

Sands Caroline J, Guha Indra N, Kyriakides Michael, Wright Mark, Beckonert Olaf, Holmes Elaine, Rosenberg William M, Coen Muireann

Abstract excerpt

OBJECTIVES: The invasive nature of biopsy alongside issues with categorical staging and sampling error has driven research into noninvasive biomarkers for the assessment of liver fibrosis in order to stratify and personalize treatment of patients with liver disease. Here, we sought to determine whether a metabonomic approach could be used to identify signatures reflective of the dynamic, pathological metabolic...

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PMID: 25533003
DOI: 10.1038/ajg.2014.370

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