Article
Lack of sustained response to teriparatide in a patient with adult hypophosphatasia.
The Journal of clinical endocrinology and metabolism - 1 Mar 2010
Gagnon Claudia, Sims Natalie A, Mumm Steven, McAuley Sybil A, Jung Caroline, Poulton Ingrid J, Ng Kong Wah, Ebeling Peter R
Abstract excerpt
INTRODUCTION: Hypophosphatasia (HPP) is a rare genetic disorder characterized by low serum alkaline phosphatase (ALP) and defective bone mineralization predisposing to poorly healing pseudofractures and fractures. Experience with teriparatide in HPP is limited. METHODS: A 53-yr-old woman was diagnosed with HPP on the basis of repeatedly low serum ALP (6-8 IU/liter; normal, 30-120 IU/liter), high urine...
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