Article
Hypophosphatasia: Canadian update on diagnosis and management.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Sept 2019
Khan A A, Josse R, Kannu P, Villeneuve J, Paul T, Van Uum S, Greenberg C R
Abstract excerpt
Hypophosphatasia (HPP) is a rare inherited disorder of bone and mineral metabolism caused by loss of function mutations in the ALPL gene. The presentation in children and adults can be extremely variable and natural history is poorly understood particularly in adults. Careful patient evaluation is required with consideration of pharmacologic intervention in individuals meeting criteria for therapy. INTRODUCTION:...
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