Article
Proposing a clinical algorithm for better diagnosis of hypophosphatasia in resource-limiting situations.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Dec 2022
Sadhukhan Sreyanko, Mehta Poonam, Rajender Singh, Gupta Sushil Kumar, Chattopadhyay Naibedya
Abstract excerpt
Early diagnosis of hypophosphatasia (HPP) is challenging. Here, we propose to broaden the diagnostic criteria of HPP by reviewing published data on BMD and fractures in HPP patients. Non-osteoporotic fractures and higher than normal lumbar BMD were recurrent in HPP patients and could be included as diagnostic criteria. HPP is a genetic disorder caused by autosomal recessive or dominant loss-of-function mutations...
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