Article
Progranulin (GRN) in two siblings of a Latino family and in other patients with schizophrenia.
Neurocase - 1 Jun 2010
Momeni Parastoo, DeTucci Karen, Straub Richard E, Weinberger Daniel R, Davies Peter, Grafman Jordan, Hardy John, Huey Edward D
Abstract excerpt
Schizophrenia has been linked to a region on chromosome 17q21 in Latino populations (Escamilla et al., 2009). Mutations of a gene at this location (GRN) are associated with frontotemporal dementia. A recent study demonstrated that patients with frontotemporal dementia who presented with symptoms of schizophrenia show neuropathological findings consistent with GRN mutations, but were not tested for GRN mutations...
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